One expert in migraine who wasn’t connected to the study was cautiously optimistic about the findings.
“It is hard to make much from one case report, [but] it does illustrate the importance of all of these non-pharmacological, evidence-based treatments,” said Dr. Noah Rosen. He directs Northwell Health’s Headache Center in Great Neck, N.Y.
As the researchers noted, more than 1 billion people worldwide have migraines, defined as one-side, pulsating headaches, sometimes with a variety of other symptoms, that last between four and 72 hours.
Some migraines are episodic, meaning they happen fewer than 15 days per month. Others are chronic, with 15 or more migraine days per month plus migraine features on eight days per month.
To be considered successful, migraine treatment must cut the frequency and length of the attacks in half or improve symptoms.
The 60-year-old man whose experiences are detailed in the report had endured severe migraine headaches without aura for more than 12 years. Six months before his clinic referral, his migraines had become chronic, occurring anywhere from 18 to 24 days each month.
He had tried a number of potential fixes, including the prescribed medications zolmitriptan and topiramate. He also cut out potential ‘trigger’ foods, including chocolate, cheese, nuts, caffeine, and dried fruit. Beyond this, the man also tried yoga and meditation to curb the attacks.
None of those interventions had worked.
The man described the pain as throbbing, starting suddenly and intensely in the forehead and temple on the left side of his head. His migraines usually lasted 72 hours and also included sensitivity to light and sound, nausea and vomiting. His pain severity was 10 to 12 out of a scale of 10.
He didn’t have high levels of systemic inflammation but had a normal level of beta carotene in his blood, possibly because he ate sweet potatoes daily. Sweet potatoes are relatively low in food nutrients known as carotenoids, which carry anti-inflammatory and antioxidant properties, the authors explained.
Leafy greens such as spinach, kale and watercress do contain high levels of carotenoids, however.
So, Dunaief’s team advised the man to adopt the Low Inflammatory Foods Everyday (LIFE) diet. It’s a nutrient-dense, whole food, plant-based diet. The regimen advocates eating at least five ounces by weight of raw or cooked dark green leafy vegetables every day, drinking one 32-ounce daily green LIFE smoothie, and limiting intake of whole grains, starchy vegetables, oils, and animal protein, particularly dairy and red meat.
After two months on the diet, the man said his migraines had been dramatically reduced — to just one migraine day per month, and even that headache was less severe.
At the same time, his blood tests showed a substantial rise in beta-carotene levels.
Soon, the man stopped taking all his migraine meds. His migraines stopped completely after three months and haven’t returned in 7 1/2 years.
The man was allergic, and previously published research suggests that better control of allergies may also lead to fewer migraine headaches. In this case, the man’s allergy symptoms also improved — to the point that he no longer needed to use seasonal medication.
He was also HIV-positive, and HIV has been linked to a heightened risk of migraines. It is possible that the man’s HIV status and antiretroviral drugs had contributed to his symptoms, the authors said, though it wasn’t possible to study this further without stopping the antiretroviral treatment.
“While this report describes one very adherent patient who had a remarkable response, the LIFE diet has reduced migraine frequency within 3 months in several additional patients,” Dunaief added.
For his part, Rosen said that “the role of proper diet and migraine has had a few studies demonstrating benefit.”
Being properly hydrated, eating a healthy “low-glycemic” diet and getting lots of omega 3 fatty acids (such as are found in oily fish) have all been shown to have a positive effect on curbing migraines, he said.
Beyond food, getting good sleep, regular exercise and psychological interventions such as “cognitive behavioral therapy, mindfulness and progressive muscle relaxation” may also help, Rosen said.
Find out more about migraines at the American Migraine Foundation.
SOURCE: BMJ Case reports, news release, Nov. 18, 2021